Abstract
Transfusion polycythemia was reproduced in Wistar rats. Preparations of homologous and heterologous DNA were injected intraperitoneally in a dose of 5 mg. On the 1st, 3rd, 5th, 10th, 15th, and 20th days after injection of DNA the erythrocytes production was determined from the Fe59 content in these cells in the peripheral blood. Despite the sharp inhibition of erythropoiesis in the polycythemic animals, injection of the preparations of exogenous DNA restored the formation of the red blood cells. The effect from injection of heterologous DNA was less than from homologous DNA. The restoration of erythropoiesis in polycythemic animals in response to injection of DNA preparations was due to the effect of the DNA on differentiation and proliferation of erythropoietin-sensitive cells.
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