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Abstract
Adaptive changes in the activities of adenyl cyclase and phosphodiesterase in response to exercise training were studied in muscle, heart, and liver. Basal adenyl cyclase activities were increased in muscle and decreased in heart as a result of training. Epinephrine-stimulated adenyl cyclase activity of heart was depressed by training. Fluoride-stimulated adenyl cyclase activity was not altered by training in any of the tissues studied. Phosphodiesterase activity was depressed in liver of trained rats but unaltered in muscle and heart. These changes in adenyl cyclase and phosphodiesterase activities suggest that the capacity to respond to hormones may be altered by training.
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