Abstract
The effect of physical exercise on lipid peroxidation was investigated. 27 healthy young adult male subjects were included in this study. Urine samples were collected before and after exercises. Urinary malondialdehyde and creatinine levels (Cr) were measured. Urinary malondialdehyde levels were increased by exercise. While pre-exercise malondialdehyde levels were 5.02 +/- 1.26 nmol/mg Cr, post-exercise levels were 6.13 +/- 1.84 nmol/mg Cr (p < 0.05). These findings indicated that physical exercise induced lipid peroxidation.
Highlights
Oxygen derived free radical damage is widely considered as etiological factors in many disorders [7]
Since it is impossible to measure free radicals directly in vivo, it is necessary to rely on the quantitation of their reaction products such as protein carbonyls, modified DNA and lipid peroxidation products
The purpose of this study was to investigate the effect of exercise on lipid peroxidation in healthy young men
Summary
Oxygen derived free radical damage is widely considered as etiological factors in many disorders [7]. Free oxygen radicals rapidly react with polyunsaturated fatty acids in the cell membranes, proteins, and other cellular components. Since it is impossible to measure free radicals directly in vivo, it is necessary to rely on the quantitation of their reaction products such as protein carbonyls, modified DNA and lipid peroxidation products. Malondialdehyde (MDA) is the most widely used index of lipid peroxidation [8]. Physical exercise can induce oxidative stress and free radical production by different mechanism. These mechanisms related to the time course and exercise intensity [2,10,11,12]
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