Effect Of Exercise On Bone Health In Postmenopausal Women With Osteoporosis

Abstract

PURPOSE: To investigate the effects of weight-bearing and jump training on bone mineral density (BMD) and content (BMC) and bone metabolism in women with postmenopausal osteoporosis (PMOP), to compare the differences in the effects of the two interventions on femoral and lumbar spine bone health, and to evaluate the implications of a community-based public health program against PMOP. METHODS:Sixty-one community-based PMOP women were studied for 12 weeks of exercise training using both weight bearing and jumping; BMD and BMC of the lumbar spine and hip femur were measured before and after the intervention using GE dual-energy X-ray bone densitometry; and the expression levels of serum bone metabolism indicators PINP and S-CTX were measured using enzyme-linked immunosorbent assay (ELISA). RESULTS:After 12 weeks of intervention, the BMD and BMC of the hip femur and lumbar spine in the weight-bearing and jumping groups showed an overall increasing trend(P < 0.05), whereas BMD and BMC of the control group decreased at all sites (P < 0.05). Relative to baseline levels, the rate of change (Δ%) in BMD and BMC for both the weight-bearing and jump groups showed a lower hip femur than lumbar L2-4, while the opposite was true for the control group. The Δ% of BMD and BMC of the femur of the weight-bearing group were higher than those of the jumping group, the situation of lumbar spine L2-4 is just the opposite. The PINP and S-CTX levels in the exercise group decreased after the intervention, while the S-CTX in the control group increased, and the S-CTX/PINP value was much smaller than that in the control group, but none of the changes were statistically significant. CONCLUSIONS: Short term exercise intervention can also effectively alleviate bone loss in postmenopausal women with osteoporosis, and have a positive impact on bone metabolism. The lumbar spine can respond better to stress stimulation than the hip femur. The osteogenesis effect of weight training on the femur is better than that of jumping training, but the effect on lumbar bone tissue is lower than that of jumping training. This Study was suppoted by the National Science and Technology Key Project 2018YFC2000600