Effect Of Exercise On Blood Lipid For Patients With Hypertension: A Network Meta-analysis

Abstract

Exercise is beneficial in reducing cardiovascular risk factors, but different types of exercise are inconsistent in improving lipid levels in hypertensive patients. Network meta-analysis allows for estimation of the relative effectiveness and rank ordering of the interventions even if head-to-head comparisons are lacking. PURPOSE: Comparing the effects of aerobic training, resistance training, aerobic combined with resistance training on blood lipid for patients with hypertension by network meta-analysis. METHODS: Searched the CNKI, CQVIP, WAN FANG Data, PubMed, Web of Science, The Cochrane Library, and Embase from inception to September 16th, 2021, to collect randomized controlled trials (RCTs) about exercises on blood lipid for patients with hypertension. Two reviewers independently screened literature, extracted data and assessed the risk of bias of included studies, and then used Stata 15.1 to conduct corresponding statistical analysis. RESULTS: A total of 29 RCTs were recalled, with 2519 patients. Compared with the control group, aerobic training [MD = -0.47,95%CI:-0.62,-0.319,P < 0.001], resistance training (MD = -0.37,95%CI:-0.63,-0.11,P < 0.05) and aerobic combined with resistance training (MD = -0.61,95%CI:0.88,-0.34,P = 0.005) had statistical significance in reducing the total cholesterol; aerobic training (MD = 0.14,95%CI:0.08,0.20,P < 0.001), resistance training (MD = 0.10,95%CI:0.02,0.19,P < 0.05) and aerobic combined with resistance training(MD = 0.12,95%CI:0.02,0.23,P = 0.038) had statistical significance in increasing the high-density lipoprotein; aerobic training (MD = -0.32,95%CI:-0.48,-0.15,P = 0.001), resistance training (MD = -0.19,95%CI:-0.48,-0.01,P < 0.05) and aerobic combined with resistance training (MD = -0.40,95%CI:-0.70,-0.11,P < 0.05) had statistical significance in reducing the low-density lipoprotein. The SUCRA probability sorting result showed that aerobic combined with resistance training had the most significant effect on total cholesterol, triglyceride, low-density lipoprotein, and high-density lipoprotein. CONCLUSION: Aerobic combined with resistance training is the most effective exercise method to improve blood lipid for patients with hypertension. Supported by the National Key R&D Program of China (2018YFC2000600).