Abstract
Abstract Lipid peroxidation in vitro of carbon tetrachloride (CCl 4 ) and ethylene dibromide (EDB) in microsomal supernatant fraction (MSF) of chick and rat livers was evaluated by measuring the malonaldehyde concentration after incubation with thiobarbituric acid. The additive peroxidation effect of CCl 4 in rat liver NADPH-induced system, was confirmed. The addition of EDB to the system had no effect on lipid peroxidation. The addition of NADPH to MSF of chick liver caused a marked increase in peroxidation. Both CCl 4 and EDB inhibited peroxidation in the above system. The different response of the two species to the CCl 4 hepatotoxicity is discussed.
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