Abstract
□ The oral bioavailability of new formulations of ceftizoxime sodium was investigated in animals and humans. In rats, one of the formulations tested showed significant improvement, with a urinary excretion of 47.7% (0-24hr). Good results were obtained also in dogs. In humans, the mean peak serum level was 3.6μg/ml at 3.3hr postadministration for formulation 10. The average ceftizoxime AUC at 0-8hr was 17.3μghr/ml and urinary excretion of ceftizoxime was 9.6% (0-24hr). The concentrations in the serum exceeded the minimum inhibitory concentrations for most of the commonly encountered bacterial pathogens.
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