Abstract
Objective To investigate effect of ethinylestradiol and cyproterone acetate (diane-35) on endocrinology and metabolism of non-obese patients with polycystic ovary syndrome (PCOS) , and insulin resistance(IR) after treatment. Methods From January 2011 to December 2012,a total of 134 non-obese patients with PCOS in Shanghai Eighth People's Hospital were enrolled into this study. Body mass index (BMI) of patients all were less than 25 kg/m2 and were treated by ethinylestradiol and cyproterone acetate for 12 months. BMI, waist to hip ratio (WHR),F-G scores,acne scores, and levels of serum total testosterone (T) ,luteinizing hormone (LH),follicle-stimulating hormone (FSH) , fasting insulin(FINS), fasting plasma glucose (FPG),homeostasis model assessment insulin resistance index (HOMA-IR) were observed before treatment and at the end of 6,12 months after treatment by ethinylestradiol and cyproterone acetate. The study protocol was approved by the Ethical Review Board of Investigation in Human Being of Shanghai Eighth People's Hospital. Informed consent was obtained from all participants. Results BMI, WHR of patients slightly increased at the end of 6,12 months after treatment by ethinylestradiol and cyproterone acetate than those before treatment, there had no significance difference (P>0. 05). Ovarian Volume, F-G scores,acne scores were lower at the end of 6 months after treatment by ethinylestradiol and cyproterone acetate than those before treatment, and reductions much lower at the end of 6,12 months after treatment by ethinylestradiol and cyproterone acetate,there all had significance difference between these two periods than those before treatment, respectively (P 0. 05). Conclusions Total T significantly reduce to normal levels during the treatment of ethinylestradiol and cyproterone acetate on non-obese patients with PCOS,but FINS,HOMA-IR have no significance deference than those before treatment by ethinylestradiol and cyproterone acetate. Key words: polycystic ovary syndrome; non-obese; ethinylestradiol and cyproterone acetate; insulin resistance
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