Abstract
Thirteen pregnant monkeys during the third trimester of their gestation were infused intravenously with ethanol (2 to 4 Gm. per kilogram) after a spontaneous onset of labor or following its induction by infusion of oxytocin. In the animals near term administration of ethanol did not alter appreciably either the intensity or frequency of uterine contractions. This pertained both to the animals in spontaneous labor and those stimulated by oxytocin. Ethanol was ineffective even in cases in which the dose was increased to a level which produced depression of maternal respiration. Only in animals before term and in which uterine contractions were irregular, partial suppression of labor was observed. This was associated with fetal hypotension, tachycardia, and acidosis, while only minimal changes were observed in the acid-base state of the mother.
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