Effect of ethanol on stretch response of muscle receptors in cats

Abstract

The response of muscle spindles and tendon organs to steady and sinusoidal muscle stretch was investigated at different blood alcohol concentrations (BAC). After initial anesthesia (pentobarbital), cats were spinalized, the lumbar ventral roots cut and the gastrocnemius muscles of one hindleg prepared for controlled stretching. The animals were paralyzed and artificial respiration was applied. Action potentials from isolated Ia/Ib/II afferent fibers could be recorded. Under steady stretch conditions, all fibers responded to an increasing BAC with an increase in firing rate. This could be observed already at 0.8 mg/ml BAC. The increase in discharge rate reached at the most 80 imp/s. During intoxication the regularity of firing was higher than in the no-alcohol situation. At blood alcohol concentrations higher than 5 mg/ml, the neuronal activity suddenly dropped to zero, exhibiting an irregular impulse pattern. The increase in discharge rate at steady stretch is regarded to be of minor significance in the explanation of the impairment of motor performance under ethanol. When sinusoidal stretch was applied, the increase in the mean discharge rate was smaller than at steady stretch conditions. Up to about 10 mg/ml BAC the periodical modulation of firing rate during sinusoidal stretch of a large amplitude remained mainly unchanged. After the discharge rate had dropped to zero for the steady stretch condition at high BAC, elicitation of action potentials was always possible using dynamic stretch.