Abstract
The effect of ethanol extract of the fruiting bodies of Pleurotus ostreatus on serum lipid profile and atherogenic indices of high sucrose high fat diet streptozotocin (HS-HFD-STZ) induced diabetic rats was determined by standard methods. All the groups were fed high sucrose-high fat diet except the normal group. The Metformin HCl and ethanol extract was given once daily by gavage to the reference and experimental groups respectively at doses of 150mg/Kg b.w., 50mg/Kg b.w, 150mg/Kg b.w. and 300mg/Kg b.w. respectively while the normal control received saline solution. The HDL-cholesterol level was higher than the value of the disease group after 6 weeks of administration of extract at 300mg/kg and after 9 weeks administration of extract at 150mg/kg. HDL cholesterol concentration increased by 22.2% after 6 weeks of extract administration at 300mg/kg and by 16.7% and 28.3% respectively after 9 weeks of extract administration at 150mg/kg and 50mg/kg respectively, indicating that the POE extract has the capacity to reduce cardiovascular diseases. At all the doses of extract administered for treatment at 3 weeks, 6 weeks and 9 weeks intervals, there was dose and time dependent lowering of LDL: HDL ratio even below the recommended risk limit of ≤ 2.5 compared to the test control with value above 2.5. After 3 weeks of treatment with extract at administration concentration level of 150mg/kg, atherogenic indices were lowered and extract levels of 150mg/kg and 300mg/kg reduced atherogenic index value after 6 weeks of administration while after 9 weeks of treatment, extract at 150mg/kg concentration reduced atherogenic indices. The atherogenic indices of the diabetic animals under treatment were dose-and time dependently reduced by POE treatment as observed in this study.These results suggest a possible use of the extracts in the management of hyperlipidemic conditions, hypertension and associated complications.
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