Abstract
Green tea (Camellia sinensis) has the potential to be developed as a natural agent for therapy of iron overload in thalassemia. The purpose of this research was to observe the ability of ethanol extract of green tea as a natural iron chelating agent in animal iron overload model. Ethanol extract of green tea leave (GTLE) was prepared by maceration using 70% ethanol. Sprague-Dawley male rats were divided into three groups (5 rats each), a normal control group (group I) received daily p.o. of deionized water, the iron overload group received 100 g/Kg BW (group II) of GTLE that given two hours before ferroussulfate0.5 g/Kg BW administrations and the last group (group III) received only 0.5 g/Kg BW of ferrous sulfate. GTLE and ferrous sulfate were given orally every day for 30 days. At the end of the experimental period, rat blood serum samples were collected. Iron content and alanine aminotransferase (ALT) levels were measured using a spectrophotometer followed by observing the histologic preparation of rat liver organ. The results showed that administration of green tea leaves ethanolic extract of 100 g/Kg BW was able to keep down iron and ALT levels in the rat blood to a normal level.
Highlights
One of the therapy management for patients with thalassemia is performing blood transfusions to maintain haemoglobin levels within normal levels (Choudhry, 2017; de Dreuzy et al, 2016)
Excessive iron levels or comonly known as iron overload, are happened due to the influence of blood transfusion. This therapy which done repeatedly will lead to iron overload in the form of hemosiderosis; siderosis myocardium often plays a role in early death of patient with thalassemia (Berdoukas et al, 2015; Saito, 2014; Saito and Hayashi, 2015)
ALT levels of Group I and Group II showed no significant difference (p
Summary
One of the therapy management for patients with thalassemia is performing blood transfusions to maintain haemoglobin levels within normal levels (Choudhry, 2017; de Dreuzy et al, 2016). Excessive iron levels or comonly known as iron overload, are happened due to the influence of blood transfusion This therapy which done repeatedly will lead to iron overload in the form of hemosiderosis; siderosis myocardium often plays a role in early death of patient with thalassemia (Berdoukas et al, 2015; Saito, 2014; Saito and Hayashi, 2015). This research was conducted to develop a green tea (Camellia sinensis) as a natural agent to overcome iron overload by evaluating other parameters regarding iron level in blood serum, alanine aminotransferase levels, and histologic preparation of rat liver organ. Scientific findings can support the use of green tea in the future as supportive therapy to overcome iron overload
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