Abstract
Background:Although postmenopausal estrogen replacement therapy is known to reduce cardiovascular mortality, the mechanism is not clear yet. Furthermore, the effect of estrogen on vascular tonus is reportedly variable according to the animal models, vascular beds and agonists used. Materials and Method:Bilate- ral ovariectomies were performed in 12 week-old, 18 spontaneously hypertensive rats (SHR and 18 normotensive Wistar-Kyoto rats (WKY. Rats were divided into three groups according to the dose of 17β - estradiol (E2 pellets implanted subcutaneously two weeks after ovariectomy;control (no implantation, low- dose (0.5 mg and high-dose (5 mg E2 replacement group. Two weeks after pellet implantation, organ bath experiments were performed using descending thoracic aortae. For endothelium-dependent relaxation, acetylcholine (10 -9 -3×10 -6 M was cumulatively added into the vessels precontracted with 10
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