Abstract
Male and female gallbladder prostaglandin biosynthesis was compared by radiochromatographic analysis of microsomal membrane fractions. Normal female rabbit gallbladder total prostaglandin activity was 10-fold higher than the normal male rabbit gallbladder total prostaglandin activity. The normal male rabbit extracts produced PGF 2α and PGE 2 as the major arachidonic acid metabolites. The normal female rabbit extracts synthesized PGI 2 and PGE 2 (20-fold higher activity than the normal male) as the major arachidonic acid metabolites present. The effect of estrogen was studied by comparing prostaglandin activity in ovariectomized female rabbits given high-dose estrogen, low-dose estrogen, and no estrogen. The zero estrogen group prostaglandin activity was 5-fold lower than the normal female group. Treatment with low- or high-dose estrogen restored the gallbladder prostaglandin activity to the level of the normal rabbit gallbladder prostaglandin activity.
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