Abstract
Treatment of mice bearing levulose sarcoma with estramustine phosphate showed a cytotoxic effect which was similar to that of cyclophosphamide. Therefore, the alkylating moiety of estramustine phosphate seems to be the main principle of the cytotoxic effect observed. However, this effect of estramustine phosphate was observed only on the levulose sarcoma among the mouse tumours examined. Estramustine phosphate also inhibited the growth of androgen dependent and independent mouse mammary tumours (SC-115 and SC-115-Independent). These effects of estramustine phosphate were also evoked by injection of estradiol-17β, 3, 17-diphosphate, therefore it seems to be due mainly to the oestrogenic activity of the compound.
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