Abstract
Estradiol-17β was administered to adult, female guinea pigs in which collagen had been labelled during rapid growth by the chronic administration of 14C-proline. In skin, treatment reduced collagen biosynthesis and increased collagen degradation for de-novo biosynthesis elsewhere. In the granuloma produced by γ-carrageenan, estradiol-17β produced no change in the total amount of newly-synthesized collagen, in the amount of 14C-label derived from the degradation of prelabelled collagen or in the amount derived by the re-utilization of acid-soluble collagen. In the uterus and metaphyseal bone, estradiol-17β increased both collagenous and non-collagenous de-novo protein biosynthesis. The proline for this was derived, at least in part, from the degradation of prelabelled collagen, probably from skin.
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