Abstract
Polyols are effective against caries-causing streptococci but the effect on oropharynx-derived pyogenic streptococci is not well characterised. We aimed to study the effect of erythritol (ERY) and xylitol (XYL) against Streptococcus pyogenes isolated from peritonsillar abscesses (PTA). We used 31 clinical isolates and 5 throat culture collection strains. Inhibition of bacterial growth by polyols at 2.5%, 5% and 10% concentrations was studied and the results were scored. Amylase levels in PTA pus were compared to polyol effectivity scores (PES). Growth curves of four S. pyogenes isolates were analysed. Our study showed that XYL was more effective than ERY inhibiting 71–97% and 48–84% of isolates, respectively, depending of concentrations. 48% of clinical and all throat strains were inhibited by polyols in all concentrations (PES 3). PES was negative or zero in 26% of the isolates in the presence of ERY and in 19% of XYL. ERY enhanced the growth of S. pyogenes isolated from pus with high amylase levels. Polyols in all concentrations inhibited the growth in exponential phase. In conclusion, ERY and XYL are potent growth inhibitors of S. pyogenes isolated from PTA. Therefore, ERY and XYL may have potential in preventing PTA in the patients with frequent tonsillitis episodes.
Highlights
Polyols are effective against caries-causing streptococci but the effect on oropharynx-derived pyogenic streptococci is not well characterised
Pyogenes isolates from peritonsillar abscesses (PTA) pus and five type collection strains with throat origin and the results were compared with the growth in BHI
Except ERY 2.5%, showed statistically relevant (p < 0.0001–0.009) inhibitory effect against PTA isolates compared to BHI. 10% xylitol was more effective than 10% erythritol (p = 0.0005)
Summary
Polyols are effective against caries-causing streptococci but the effect on oropharynx-derived pyogenic streptococci is not well characterised. We aimed to study the effect of erythritol (ERY) and xylitol (XYL) against Streptococcus pyogenes isolated from peritonsillar abscesses (PTA). Our study showed that XYL was more effective than ERY inhibiting 71–97% and 48–84% of isolates, respectively, depending of concentrations. 48% of clinical and all throat strains were inhibited by polyols in all concentrations (PES 3). ERY enhanced the growth of S. pyogenes isolated from pus with high amylase levels. ERY and XYL are potent growth inhibitors of S. pyogenes isolated from PTA. While xylitol has been shown to have inhibitory effect against lactobacilli[14], to impact biofilm formation of Staphylococcus aureus and Pseudomonas aeruginosa[15], and erythritol to play role in Brucella melitensis virulence[16], characterization of the potential effect of polyols against important oropharynx derived pathogens such as S. pyogenes, is insufficient so far
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