Effect of ERK1/2 and Bid on no-reflow phenomenon after emergency PCI in elderly patients and clinical significance

Abstract

Objective By detecting the expression of ERK1/2 and Bid mRNA in monocytes on no-reflow phenomenon after emergency percutaneous coronary intervention(PCI) in elderly STEMI patients, to investigate the effect of ERK1/2 and Bid on no-reflow phenomenon in elderly patients after emergency PCI and clinical significance. Methods The patients with STEMI accepting emergency PCI were selected as study subjects. Twelve patients with no-reflow phenomenon(classed by TIMI flow grade) as NF group, 19 patients with good perfuse as reperfusion (RF)group, 15 elderly healthiers were selected as control group. The expression of ERK1/2 and Bid were examined by RT-PCR. At the same time, TC, TG, LDL-C, HDL-C, BUN, CR, UA were detected. Results Expression of ERK1/2 and Bid mRNA in study group were significantly higher than those of control group(P<0.05). Expression of ERK1/2 mRNA in NF group was significantly lower than that of RF group(P<0.05); the expression of Bid mRNA in NF group was significantly higher than that of RF group(P<0.05). The expression of ERK1/2 mRNA had negative correlation with Bid mRNA(r =-0.69, P<0.05)). Conclusions Expression of ERK1/2 and Bid mRNA increase in elderly patients of STEMI; ERK1/2 and Bid may be involved in no-reflow phenomenon in elderly patients after emergency PCI. Key words: ERK1/2 signaling pathway; Emergency; Percutaneous coronary intervention(PCI); Elderly; No-reflow phenomenon; Bid