Abstract
The effluent from an isolated perfused pancreas infused with epinephrine (75 mg/min) contains some substance, not insulin, which, when infused into isolated rat liver caused increased uptake of alpha aminoisobutyric acid and increased release of glucose by the liver. The action of this substance on the liver closely resembles that of glucagon and it is proposed that the substance released from the pancreas is indeed glucagon.
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