Abstract
To investigate the nature of the diminished hyperglycemic response to epinephrine in pertussis-sensitized rats, we compared the response to epinephrine of the hepatic enzymes, glycogen phosphorylase and glycogen synthetase, and of peripheral lactate release in normal and sensitized rats. The epinephrine-induced activation of hepatic phosphorylase was markedly diminished in pertussis rats. Pertussis sensitization did not alter either the decrease in hepatic glycogen synthetase activity or the elevation of plasma lactate produced by epinephrine administration. The findings indicate that a diminished activation of hepatic phosphorylase, associated with and possibly dependent upon a relative hyperinsulinism, can account for the attenuated hyperglycemic response to epinephrine in pertussis rats.
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