Abstract
a peer-reviewed, open access online international journal which publishes original research papers. The journal welcomes submission from scholars and experts for possible publication from all over the world. The scope of the journal includes: Pharmaceutical research, chemistry and biochemistry of naturally occurring compounds, biological evaluation of crude extracts, ethnomedicine, traditional and complementary medicine, ethnopharmacology, biomedical research, Biotechnology, Evaluation of natural substances of land and sea and of plants, microbes and animals, pharmacognosy, bioavailability, clinical, pharmacological, toxicological studies and pharmacokinetics of phytochemicals, Isolation and characterization of compounds, structure elucidation, synthesis and experimental biosynthesis of natural Product as well as developments of methods in these areas are welcomed in the journal.
Highlights
The main threats to human health from heavy metals are associated with exposure to lead, cadmium [Cd], mercury and arsenic
It has been demonstrated that low dosage of cadmium (50 μg/day) adversely affects mammalian reproductive function, with effects that include the disruption of testis and epididymis histology, damage to spermatogenesis, a decrease in sperm motility, a change in sperm morphology and a decrease in the acrosome reaction rate in rats.[6]
The animals administered with CdCl2 showed a significant reduction in body weight from day 14 onwards whereas animals co-administered with vitamin C prevented the reduction of body weight when compared to the control
Summary
The main threats to human health from heavy metals are associated with exposure to lead, cadmium [Cd], mercury and arsenic. Drinking water and beverages contaminated with heavy metals such as arsenic, cadmium, nickel, mercury, chromium, zinc, and lead is becoming a major health concern for the public and health care professionals. It has been demonstrated that low dosage of cadmium (50 μg/day) adversely affects mammalian reproductive function, with effects that include the disruption of testis and epididymis histology, damage to spermatogenesis, a decrease in sperm motility, a change in sperm morphology and a decrease in the acrosome reaction rate in rats.[6] The epididymis and vas deferens are extremely important accessary organs that play vital roles in sperm maturation and storage. It has been demonstrated that cadmium exposure in rats (2 mg Cd/kg body mass/day) led to alkalization of the lumen fluid of the epididymis and vas deferens by direct inhibition of Proton-pumping ATPase (H+ATPase) function.[7,8] Natural antioxidants are gaining major attention in the management of oxidative stress-induced inflammatory disorders in the cardiovascular, metabolic and reproductive systems. The present study is planned to investigate the effect of EGCG on CdCl2-induced changes in behavior, biochemical parameters and spermatogenesis of male Sprague Dawley (SD) rats
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