Abstract
Background: Pulpitis is an inflammatory pulp that can caused by pulp perforation by mechanical injury. Emergency treatment of pulpitis is using Eugenol. High concentrations of Eugenol have a cytotoxic effect that causes local necrosis and inhibits the healing process. Because of negative effects from eugenol, then it’s necessary to consider a new ingredient with minimal side effects, and it’s epigallocatechin-3-gallate (EGCG) in green tea. As a polyphenol, it has good antioxidant effect and plays a role in shortening the duration of inflammation by radical scavenging against Nitric Oxide so that NO levels rapidly decrease which causes migration of neutrophil cells to the area of injury will decrease and the inflammatory process faster so that the healing process become faster. Lymphocyte is plays a role in tissue repair. Purpose: to explain the effect of EGCG hydrogel on the number of lymphocyte cells in pulp inflammation with mechanical injury. Methods: The study used 24 Wistar rats divided into four groups, namely control (C), and 3 groups of treatment (T1, T2, T3). Each group consisted of 6 rats prepared, then EGCG hydrogel 60 ppm was named T1, EGCG hydrogel 90 ppm was named T2, EGCG hydrogel 120 ppm was named P3. On the 3rd day, Wistar rats were decapitated for HPA preparations. Results: This study showed a significant difference in each group (p < 0.05) using One-Way Anova analysis. Conclusion: EGCG hydrogel 90 ppm is effective in increasing the number of lymphocyte cells in inflammation of the pulp with mechanical injury.
Highlights
Based on Al-Hisayat’s research (2006) showed that the prevalence of perforation in dental pulp as much as 44.1% of 204 pulpitis teeth caused by mechanical injury.[1]
The study was conducted to explain the effect of EGCG as one of the polyphenol flavonoid compounds and determine the effectiveness of EGCG hydrogel 60 ppm, 90 ppm, 120 ppm on the number of lymphocyte cells that play a role in the healing process of pulpitis due to mechanical injury on day 3 in Wistar rats models
The material used in this study is EGCG which is the result of extraction from green tea, EGCG dissolved with polyethylene glycol (PEG) hydrogel base with 60 ppm, 90 ppm, and 120 ppm concentrations
Summary
Based on Al-Hisayat’s research (2006) showed that the prevalence of perforation in dental pulp as much as 44.1% of 204 pulpitis teeth caused by mechanical injury.[1]. Lymphocytes are a type of white blood cell and include chronic inflammatory cells found in chronic pulpitis.[6,5] Lymphocytes migrate to the lesion area on the 3rd day after injury until the 7th day.[7,8] Lymphocytes play a role in the process of bacterial phagocytosis and play a role in stimulating fibroblasts for the formation of new tissue by secreting FGF with macrophages. The study was conducted to explain the effect of EGCG as one of the polyphenol flavonoid compounds and determine the effectiveness of EGCG hydrogel 60 ppm, 90 ppm, 120 ppm on the number of lymphocyte cells that play a role in the healing process of pulpitis due to mechanical injury on day 3 in Wistar rats models
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