Abstract
Summary1. Intracardiac injection of maximal lethal doses of endotoxin resulted in grossly apparent edema and congestion and microscopic hemorrhages of small intestine within 20 to 80 minutes. 2. Succinoxidase activity of small intestinal mucosal homogenate decreased within 30 seconds after endotoxin injection and remained depressed until animal was moribund. 3. By assay procedure used, there was no change in amount of succinoxidase inhibitor in the intestinal homogenate. 4. Transmural migration of bacteria through the bowel wall was not apparent despite the effect of endotoxin on gut morphology and enzyme activity.
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