Abstract
Five intraperitoneal injections of endothelin-1 (100 microg/kg) to newborn albino rats on days 2-6 of life did not change the number of nuclei expressing PCNA in the left-ventricular myocardium. The number of nucleoli, area and perimeter of cardiomyocytes (isolated by the method of alkaline dissociation) increased. The number of myocyte nuclei in the state of apoptosis (evaluated by the TUNEL method) increased significantly. Presumably, partial loss of cardiomyocytes as a result of apoptosis activation after treatment with endothelin-1 is compensated by increased size and transcription activity of remaining cardiomyocytes.
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