Abstract

通过实时PCR及蛋白质印迹法测定肝组织中Toll样受体(TLR)4 mRNA及蛋白质表达,并检测血清丙氨酸转氨酶(ALT)、天冬氨酸转氨酶(AST)水平,研究大黄素对脂多糖诱导小鼠急性肝损伤的作用及其机制。结果显示大黄素处理各组肝组织中TLR4 mRNA及蛋白质表达水平、血清中ALT和AST水平均明显低于模型组,大黄素能减轻脂多糖诱导的肝组织病理学损伤。提示大黄素可能通过抑制TLR4的表达而对脂多糖诱导的急性肝损伤起保护作用。.

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