Effect of electronic compensation on plethysmographic airway resistance measurements

Abstract

To compare the performance of a plethysmograph which incorporated electronic compensation (Jaeger) to one which incorporated a heated humidified breathing system (Hammersmith plethysmograph). The performance of a plethysmograph which incorporated electronic compensation would be impaired compared to that which incorporated a heated humidified system. In vitro and in vivo comparison. Eleven children, median postnatal age 13 (range 5-15) months. In vitro, the plethysmographs were assessed using known resistances (1.94, 4.85, and 6.80 kPa, equivalent to 20, 50, and 70 cm H(2)O/L/sec, respectively). In vivo, comparison was made of the results of children studied in both plethysmographs. In vitro, the resistance results of the two plethysmographs were similar to each other and to the known resistances. In vivo, the median "effective" airways resistance result of the Jaeger (4.15 kPa/L/sec) was significantly higher than the inspiratory resistance of the Hammersmith plethysmograph (3.0 kPa/L/sec), but the median inspiratory resistances of the Jaeger were significantly lower than those of the Hammersmith plethysmograph (2.8 kPa/L/sec vs. 3.0 kPa/L/sec). The mean within patient coefficient of variability for inspiratory resistance of the Jaeger plethysmograph (16.7%) was significantly higher than that of the Hammersmith plethysmograph (11.6%) (P = 0.014). These results suggest plethysmographs which incorporate electronic compensation may be inappropriate for use in infants and very young children.