Abstract
Purpose: To investigate the effect of electroacupuncture modulating synovial autophagy on the improvement of joint function and the effect of serum interleukin (IL)-1, tumor necrosis factor (TNF)-α and matrix metalloproteinase (MMP)-3 levels in patients with osteoarthritis of the knee (KOA). Methods: Ninety-eight patients with KOA were selected and randomly divided into a control group and an observation group of 49 patients each according to the random number table method. 2 groups were given glucosamine sulfate capsules orally, 0.5g each time, 3 times a day; the control group was fumigated with a self-prescribed prescription of reeducation of paralysis once a day for 4 weeks; the observation group was given electroacupuncture therapy once every 2 days for 4 weeks on the basis of fumigation of traditional Chinese medicine. 4 weeks later, the 2 groups were compared. Group knee motion function Lysholm scale (LKSS score), visual analogue score (VAS score), Western Ontario and McMaster University Osteoarthritis Index (WOMAC score), and changes in serum IL-1, TNF-α, and MMP-3 levels. Results: After treatment, the LKSS score was significantly higher than that of the control group (P<0.01), and the WOMAC scale index and VAS score were significantly lower than that of the control group (P<0.01); after treatment, the serum IL-1, TNF-α, and MMP-3 levels were significantly lower than that of the control group (P<0.01). Conclusions: Electroacupuncture regulates synovial autophagy in the treatment of KOA, which can effectively improve the joint function of patients, and its mechanism may inhibit synovial inflammation and delay synovial cartilage degeneration by down-regulating IL-1, TNF-α and MMP-3 levels, thus playing a certain therapeutic role in KOA.View Large Image Figure ViewerDownload Hi-res image Download (PPT)View Large Image Figure ViewerDownload Hi-res image Download (PPT)
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