Effect of electroacupuncture combined with ginger-isolated moxibustion on endometrial receptivity in infertile patients with polycystic ovarian syndrome: 电针联合隔姜灸对多囊卵巢综合征不孕患者子宫内膜容受性的影响

Abstract

ObjectiveTo observe the effect of the combined therapy of electroacupuncture (EA) and ginger-isolated moxibustion on endometrial receptivity in the patients with polycystic ovarian syndrome (PCOS). MethodsA total of 70 subjects of PCOS were randomized into two groups, 35 cases in each one. In the western medication group, letrozole and human chorionic gonadotropin (HCG) were administered. In the combined therapy group, on the base of the treatment as the western medication group, the artificial cycle therapy with EA and ginger-isolated moxibustion was provided. The treatment duration was 3 menstrual cycles in two groups. After treated for 3 menstrual cycles, the symptom score of traditional Chinese medicine (TCM), endometrial thickness, the number of ovulation cycle, endometrial morphology, bilateral uterine artery pulsatility index (PI), resistance index (RI), the sum of peak systolic velocity/end diastolic velocity (S/D) and pregnancy were compared in the patients between two groups. Results(1) After treatment, the endometrial thickness was better (0.21 ± ± 0.13 vs 0.14 ± 0.08, P < 0.01), TCM symptom score reducing range was larger (5.00 ± 2.24 vs 0.52 ± 1.66, P < 0.01), the reducing degrees of bilateral uterine artery PI, RI and S/D sum were better (0.62 ± 0.26 vs 0.04 ± 0.15, 0.08 ± 0.05 vs 0.01 ± 0.05, 0.61 ± 0.33 vs 0.07 ± 0.17, 0.11 ± 0.05 vs 0.01 ± 0.05, 4.80 ± 1.14 vs 0.15 ± 0.89, all P < 0.01) in the combined therapy group respectively as compared with the western medication group. After treatment, the number of ovulation cycle and the proportion of A + B type of endometrial morphological were higher in the combined therapy group (2.09 ± 0.78 vs 1.27 ± 0.84, 87.5% vs 60.61%, P < 0.01, P < 0.05) as compared with the western medication group respectively. (2) The clinical pregnancy rate was 56.25% in the combined therapy group, better than 30.30% in the western medication group (P < 0.05). The early abortion rate was 10.53% in the combined therapy group, lower than 50.00% in the western medication group (P < 0.05). ConclusionThe combined treatment of electroacupuncture and ginger-isolated moxibustion with western medication effectively improves endometrial receptivity, increases clinical pregnancy rate and reduces early abortion rate in the patients with PCOS.