Abstract
The development of resistance to pneumococcus infection in young rats following the oral administration of various pneumococcus products has been reported by Ross.1 Feeding of pneumococcus cultures to rats and rabbits was also done by Maeji2 with similar results. That the mucous membrane of the gastro-intestinal tract is an effective site for the introduction of antigen, for the purpose of protecting the animal against pneumococcus infection, is also indicated in the work of Cooper3 on sub-mucosal injection of vaccines in rabbits. Besredka4 has shown that bile is useful in sensitizing or preparing the intestinal mucosa for the absorption of antigens; Arnold5 and Finder6 have investigated the effect of bile and egg-white on gastric secretion and on intestinal permeability to bacteria and antigens. The latter work shows that following the ingestion of egg-white and bile separately or in mixtures there is a definite lack of gastric response and an increased permeability of the small intestine.The present wor...
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