Effect of egg donor age and recipient lining thickness on implantation rates with egg donation cycles

Abstract

ObjectiveTo study the influence of donor age and recipient endometrial lining thickness on implantation rates with egg donation.DesignRetrospective review of implantation rates according to recorded factors in our IVF/egg donor database.Materials and MethodsFor analysis of donor age, all (474) egg donation cycles with a fresh embryo transfer between January 2003 and March 2011 were included. For analysis of recipient lining thickness, all (339) egg donation cycles with a maximal lining thickness recorded and a fresh embryo transfer between January 2005 and March 2011 were included.The cycles were split into 2 groups for analysis of each variable. Donor age was split and analyzed as 18-25 vs. 26-31. Recipient lining thickness was analyzed as 5.9-7.9mm vs. 8-23mm.Egg donation outcomes were compared using implantation rates (number of fetal hearts on ultrasound divided by number of embryos transferred). Statistical analysis utilized Student's t-test and chi-square statistics. Significance was defined as P<0.05.ResultsTable 1Number of CasesFetal Hearts/ETImp RateP ValueLining 5.9-7.9mm4048/7762.3%0.79Lining 8.0-23mm299351/57860.7%0..79Donor Age 18-25341382/66357.6%0.18Donor Age 26-31133163/26162.5%0.18 Open table in a new tab ConclusionCouples undergoing IVF using donor eggs often desire a very young donor with the idea that they will be more likely to get pregnant. Our study shows no statistical difference in implantation rates with egg donation cycles according to the age of the donor (up through age 31).There is much discussion in the literature about the impact of endometrial lining thickness on uterine receptivity. Our study shows no significant difference according to the thickness of the recipient's endometrial lining. This issue deserves further study. ObjectiveTo study the influence of donor age and recipient endometrial lining thickness on implantation rates with egg donation. To study the influence of donor age and recipient endometrial lining thickness on implantation rates with egg donation. DesignRetrospective review of implantation rates according to recorded factors in our IVF/egg donor database. Retrospective review of implantation rates according to recorded factors in our IVF/egg donor database. Materials and MethodsFor analysis of donor age, all (474) egg donation cycles with a fresh embryo transfer between January 2003 and March 2011 were included. For analysis of recipient lining thickness, all (339) egg donation cycles with a maximal lining thickness recorded and a fresh embryo transfer between January 2005 and March 2011 were included.The cycles were split into 2 groups for analysis of each variable. Donor age was split and analyzed as 18-25 vs. 26-31. Recipient lining thickness was analyzed as 5.9-7.9mm vs. 8-23mm.Egg donation outcomes were compared using implantation rates (number of fetal hearts on ultrasound divided by number of embryos transferred). Statistical analysis utilized Student's t-test and chi-square statistics. Significance was defined as P<0.05. For analysis of donor age, all (474) egg donation cycles with a fresh embryo transfer between January 2003 and March 2011 were included. For analysis of recipient lining thickness, all (339) egg donation cycles with a maximal lining thickness recorded and a fresh embryo transfer between January 2005 and March 2011 were included. The cycles were split into 2 groups for analysis of each variable. Donor age was split and analyzed as 18-25 vs. 26-31. Recipient lining thickness was analyzed as 5.9-7.9mm vs. 8-23mm. Egg donation outcomes were compared using implantation rates (number of fetal hearts on ultrasound divided by number of embryos transferred). Statistical analysis utilized Student's t-test and chi-square statistics. Significance was defined as P<0.05. ResultsTable 1Number of CasesFetal Hearts/ETImp RateP ValueLining 5.9-7.9mm4048/7762.3%0.79Lining 8.0-23mm299351/57860.7%0..79Donor Age 18-25341382/66357.6%0.18Donor Age 26-31133163/26162.5%0.18 Open table in a new tab ConclusionCouples undergoing IVF using donor eggs often desire a very young donor with the idea that they will be more likely to get pregnant. Our study shows no statistical difference in implantation rates with egg donation cycles according to the age of the donor (up through age 31).There is much discussion in the literature about the impact of endometrial lining thickness on uterine receptivity. Our study shows no significant difference according to the thickness of the recipient's endometrial lining. This issue deserves further study. Couples undergoing IVF using donor eggs often desire a very young donor with the idea that they will be more likely to get pregnant. Our study shows no statistical difference in implantation rates with egg donation cycles according to the age of the donor (up through age 31).