Abstract
Caries progress might be controlled when collagen matrix could be preserved after demineralization. The aim of this study was to investigate the effect of EGCG, a major polyphenol of green tea, on changes in loss of dry weight or solubilization of collagen from demineralized dentin sections. Dentin sections (1mm×5mm×5mm) were completely exposed to the acetic acid solution to form dentine caries. After baseline measurements of dry mass, the samples were divided into 2 groups and incubated at 37°C in either media containing EGCG or artificial saliva only for 24h, 3 days, 1 week, 2 week and 3 weeks. Following hydrolyzed with HCl, hydroxyproline (HOP) as an index of solubilization of collagen was analysed quantitatively. Both the storage medium and the storage time showed significant effects on mass loss and HOP release (p < 0.05). The incubation in EGCG resulted in relatively rapid and significant (p < 0.05) decrease in the amounts of mass loss. The HOP content of the experimental media also increased with incubation time but was significantly lower (p < 0.05) than in the control artificial saliva medium. It can be concluded that EGCG can inhibit collagen degradation and affects the further demineralization in dentin matrix, which consequently inhibits the advanced dentine caries.
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