Abstract
Background: It is reported that one of the pathophysiological factors involved with functional dyspepsia (FD) is gastric adaptive ralaxation (GAR). We have reported that it is possible to estimate more physiological gastric reservoir ability by measuring the cross section area of proximal stomach. Ecabet sodium (ES), mucoprotective antiulcer agents, is known to relax the stomach by endogenous nitric oxide (NO) mediation in an animal experiment. However, it is still unknown whether ES induces GAR in human stomach. Aim: We examined the effects of ES on GAR and intragastirc pressure in Japanese patients. Material and Methods: Fourteen healthy male volunteers, (age: 38.6 ± 2.1, BMI: 24.9 ± 0.4 kg/m2) have joined this study. After an overnight fast, examination began in early morning. An intragastric pressure sensor (Synetic Medical Micro Digitrapper 2 Mb) was inserted through the nose to the stomach about 50 cm, and abdominal ultrasonography (US; Toshiba Medical SSA-770, central frequency: 3.75 Mhz, convex probe) was performed intermittently when the volunteers drunk 500 ml mineral water by 100 ml with and without preparative administration of ES on separate days. Results: Intragastric pressure temporarily dropped after the volunteers drunk 100 ml water with or without ES intake. Moreover, intragastric pressure had a tendency to be lower after the ES intake. US revealed the expansion of proximal stomach depending on the water intake volume. After taking ES, US revealed that the cross section area of proximal stomach was bigger with significant difference when drinking 300 ml and 400 ml thus suggesting that ES expand proximal stomach faster. Conclusion: ES promotes GAR in human stomach, and it can be applicable in FD patients.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
