Effect of early hyperbaric oxygen therapy on advanced brain function and inflammatory factors in patients with vascular dementia

Abstract

Objective To investigate the effect of hyperbaric oxygen therapy on advanced brain function and inflammatory factors in patients with vascular dementia. Methods Eighty-two patients with vascular dementia from June 2014 to December 2015 were selected as the study objects. According to the random number table method, the patients were divided into observation group and the control group, with 41 cases in each group. The control group was treated with Shuxuening injection and was given corresponding pressure control and blood glucose-lowering measures according to the condition of patients’ blood pressure and blood glucose. Based on this, the observation group was treated with hyperbaric oxygen. Both of the two groups were treated for 2 weeks. The cognitive function, balance function and motor function were compared between the two groups before and after treatment. Meanwhile, serum C reaction protein (CRP), interleukin-6 (IL-6) and tumor necrosis factor gamma (TNF-γ) levels were analyzed. Results LOTCA score (100.23±5.38), BBS score (49.36±2.07) and Fugl-Meyer score (90.38±2.51) of the observation group were significantly higher than those of the control group (P<0.05). The levels of CRP [(2.43±1.34) mg/L], IL-6 [(19.41±4.23) ng/L] and TNF-γ [(111.45±4.72) ng/L] in the observation group were significantly lower than those in the control group (P<0.05). Conclusions Early hyperbaric oxygen therapy can effectively improve the advanced brain function of patients with vascular dementia, and have positive effect on the control of serum inflammatory factors. It is worthy of wide use in clinics. Key words: Early; Hyperbaric oxygen therapy; Vascular dementia; Advanced brain function; Inflammatory factors