Effect of early CRRT intervention on immune function in patients with severe pneumonia complicated with acute kidney injury

Abstract

Objective To observe the effect of early continuous renal replacement therapy (CRRT) intervention on immune function in patients with severe pneumonia and acute kidney injury. Methods 76 patients with severe pneumonia complicated with acute kidney injury were divided into CRRT group and control group by random number table method.The control group received routine anti-infective symptomatic support treatment, while the CRRT group received early CRRT treatment on the basis of routine treatment.The changes of serum creatinine, C-reactive protein, neutrophil phagocytosis index and CD4+ /CD8+ ratio were recorded after 4, 8 and 24 hours of treatment, and the acute physiology and chronic health status score (APACHE Ⅱ) were evaluated before and after treatment. Results There was no significant difference in the four indexes between the two groups before and after treatment for 4 hours.After treatment for 8 hours and 24 hours, the serum creatinine level in CRRT group decreased significantly (P<0.05), C-reactive protein level decreased significantly (P<0.05), neutrophil phagocytosis index increased significantly (P<0.05), lymphocyte CD4+ /CD8+ ratio increased significantly (P<0.05). There was statistical significance.At the same time, APACHE Ⅱ scores of the two groups after treatment were lower than those before treatment, and CRRT scores were significantly lower than those of the control group (P<0.05). Conclusions Early CRRT intervention has a positive effect on the improvement of immune function in patients with severe pneumonia complicated with acute kidney injury. Key words: Continuous renal replacement therapy; Severe pneumonia; Acute kidney injury; Immune function