Abstract
Background: a metabolic condition characterized by a failure in the metabolism of proteins, lipids, and carbohydrates that is brought on by problems with insulin production. When multiple autoantibodies, such as those against glutamic acid decarboxylase, are present against different insulin antigens, type 1 diabetes is present. Objective: To estimate the Glutamic Acid Decarboxylase Autoantibodies and assessment of HbA1c in type 1 DM. Methods: 40 children with diabetes participated, while 10 kids in the control group had blood sugar levels that were normal. HbA1c levels for each participant are measured as part of a quantitative ELISA test for the identification of circulating autoantibodies against glutamic acid decarboxylase in human serum. Results: All the pathological samples showed an increase in the concentration of Anti-GAD compared to the control. Samples of patients with diabetes for 5 years or more showed a decrease in Anti-GAD concentration compared to patients with diabetes for less than five years, but the decrease was not significant Conclusion: There was positive association between duration of type 1 Diabetes Mellitus and Glutamic Acid Decarboxylase Autoantibodies
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