Abstract
BackgroundThe aim of the present study is to evaluate the association between BMD and type 2 DM status in middle-aged and elderly men. To investigate a possible correlation, the present study used the BMD dataset of the Korea National Health and Nutrition Examination Survey (KNHANES) from 2008 to 2011.MethodsIn total, 37,753 individuals participated in health examination surveys between 2008 and 2011. A total of 3383 males aged ≥50 years were eligible. They underwent BMD measurement through dual-energy X-ray absorptiometry (DXA). The fasting plasma glucose and insulin levels of participants were also measured.ResultsMen with prediabetes and diabetes had significantly higher mean BMD at all measured sites than control men did, irrespective of DM status. This was confirmed by multivariable linear regression analyses. DM duration was an important factor affecting BMD. Patients with DM for > 5 years had lower mean BMD in the total hip and femoral neck than those with DM for ≤5 years. Per multivariable linear regression analyses, patients with DM for > 5 years had significantly lower mean BMD at the femoral neck than those with DM ≤5 years.ConclusionsDM duration was significantly associated with reduced femoral neck BMD.
Highlights
The aim of the present study is to evaluate the association between bone mass density (BMD) and type 2 diabetes mellitus (DM) status in middle-aged and elderly men
Baseline characteristics of the participants based on type 2 DM status Among all participants aged ≥50 years of the 2008–2011 Korea National Health and Nutrition Examination Survey (KNHANES), 1037 (29.76%) men had prediabetes, and 644 (18.57%) men had DM
We investigated the correlation between BMD and body mass index (BMI) in the group with DM
Summary
The aim of the present study is to evaluate the association between BMD and type 2 DM status in middle-aged and elderly men. Type 2 diabetes mellitus (DM) is a common metabolic disease with an increasing worldwide prevalence rate of 8.3% [1], and with 11% among Korean male adults. Considering that more than 9 million osteoporotic fractures are recorded annually worldwide, osteoporosis is a significant contributor to morbidity and lost life years globally [2]. Osteoporosis and type 2 DM share many common characteristics in that they are both chronic diseases with an increasingly global medical burden. As many as one in four men aged > 50 years will develop at least one osteoporosis-related fracture in his lifetime, highlighting the need for more studies on osteoporosis in men [6]. One in three men die in within a year after a hip fracture, another one in three experience a subsequent
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