Effect of Duration from Diagnosis of Clinical Chorioamnionitis to Delivery on Short Term Neonatal Outcomes [22Q

Abstract

INTRODUCTION: Clinical chorioamnionitis (CC) is associated with poor neonatal outcomes. It is not well known if the duration from diagnosis of CC to delivery has an impact on neonatal outcome. Our hypothesis is that the duration from diagnosis of CC to delivery at term does not affect the short term neonatal outcome. METHODS: This is a retrospective cohort study of patients >37 weeks gestation diagnosed with CC at a single tertiary care hospital from Jan 1, 2015 to December 31, 2017. Medical records were reviewed for maternal demographics and neonatal records were reviewed for length of NICU stay, total hospital stay, 5 minute APGAR score and presence of bacteremia. Patients were grouped by duration of diagnosis of CC to delivery <4 hours and> 4 hours. Mann Whitney test, Fisher's exact test and t-test were performed when appropriate. RESULTS: 131 patients met inclusion criteria. 94 women delivered within 4 hours of diagnosis of CC and 37 women delivered after 4 hours of diagnosis. There was no difference in length of NICU stay, length of hospital stay, 5 minute APGAR score or neonatal bacteremia. When comparing time of diagnosis to delivery at time points of 1 and 6 hours, there was no difference in neonatal length of hospital stay. CONCLUSION: Time to delivery after diagnosis of chorioamnionitis at term does not appear to affect short term neonatal outcomes.