Effect of duodenal-jejunal bypass vs.Roux-en-Y gastric bypass for type II diabetes

Abstract

Objective To study the curative effects of Roux-en-Y gastric bypass vs.duodenal-jejunal bypass for STZ-induced type 2 diabetic SD rats.Methods Twenty-one type Ⅱ diabetic rats were randomly divided into Roux-en-Y gastric bypass group and duodenal-jejunal bypass group.The fasting blood glucose,fasting plasma insulin level,the body weight and the food intake were measured and recored before and after operation at the 1st,2nd,3rd,4th and 8th week postoperatively.Results As compared with preoperation,fasting plasma glucose levels in DJB group were markedly declined at the 3rd,4th and 8th week (18.30 ±4.4 vs.11.30 ±5.02 vs.9.80 ±4.81 vs.7.90 ±3.38,P ＜0.05),fasting plasma insulin levels increased significantly at the 3rd,4th and 8th week (11.10 ± 5.69 vs.15.50 ± 3.68 vs.16.60 ±3.67 vs.16.70 ±3.74,P ＜0.05).Body weight was decreased but the difference was statistically significant only at the 8th week after surgery (368.30 ±23.69 vs.352.20 ±35.28,P＜0.05).Food intake was markedly declined only at the 1st week after DJB (30.40 ± 1.94 vs.15.30 ± 10.78,P ＜0.05).In the RYGB group,as compared with preoperation,fasting plasma glucose levels were markedly declined at 3rd,4th and 8th week (19.30±4.89 vs.13.50±4.05 vs.9.80±3.08 vs.8.60 ±2.71,P＜0.05),and body weight was also markedly declined at 3rd,4th and 8th week (370.70 ±41.88 vs.343.20 ±31.16 vs.322.70 ± 34.76 vs.304.70 ± 29.70,P ＜ 0.05),insulin levels significant increased at 3rd,4th and 8th week (10.50 ± 4.13 vs.16.50 ± 4.93 vs.18.80 ± 3.36 vs.18.40 ± 2.82,P ＜ 0.05).Food intake was decreased significantly after surgery (12.90 ± 7.82 vs.20.10 ± 1.41 vs.19.80 ± 2.35 vs.20.70 ± 1.83 vs.20.30 ±2.42,P ＜0.05).From the baseline to 8th week,no significant difference was found between RYGB group and DJB group in fasting plasma glucose and insulin levels (P ＞ 0.05),but there was significant difference in weight loss between two groups (P ＜ 0.05).Food intake after surgery was significantly less in the RYGB group than in the DJB group (P ＜ 0.05).Conclusion DJB is effective in controlling glycemia,and the effect in improving glycemia has no significant difference with RYGB,but it has no effect on food intake and tiny effect on body weight. Key words: Diabetes; Duodenal-jejunal bypass ; Roux-en-Y gastric bypass; Effect