Effect of dried kiwi and kumquat fruits against azathioprine induced liver toxicity in male albino rats

doi:10.21608/enj.2021.177743

Abstract

Highlights

Azathioprine (AZA) is a type ofimmunosuppressant medicine used in organ transplantation andautoimmune conditions include rheumatoid arthritis andpemphigus disease or chronic bowel disease like crohnan ulcerative colitis disease Manikandaselvi et al, (2015).It is a prodrug, converted into the active metabolite of 6mercaptopurine and 6-thioiosinic acid in the body, weakening the immune response, and reducing the amount of white blood cells that battle infection
The second group was daily received 10 mg/kg from azathioprine dissolved in saline by gavage for 7 days to induce liver toxicity Manikandaselvi et al, (2015).After that, the second group was divided into equal 7 subgroups (n = 6 each) as follow: One of these groups kept as positive (+ve) control group and received basal diet only, the others gave the experimental fruits in powder form mixed with the basal diet as follow respectively
The body weight gain (BWG%), feed intake(FI), feed efficiency ratio(FER) and relative liver weight were calculated according to Chapman et al, (1959)

Summary

Introduction

Azathioprine (AZA) is a type ofimmunosuppressant medicine used in organ transplantation andautoimmune conditions include rheumatoid arthritis andpemphigus disease or chronic bowel disease like crohnan ulcerative colitis disease Manikandaselvi et al, (2015).It is a prodrug, converted into the active metabolite of 6mercaptopurine and 6-thioiosinic acid in the body, weakening the immune response, and reducing the amount of white blood cells that battle infection. Azathioprine can affect rapidlygrowing cells including bone marrow and gastrointestinalcells, and increase susceptibility to infection andhepatotoxicity )Nørgård et al, 2004); Wu et al, 2006).,AZA is mutagenic, genotoxic, teratogenic andseveral types of tumors are associated with prolongedtreatment with it)Langer et al, 2003);Marcen et al, 2003;Karawya and ElNahas, 2006). Some studies have suggested thatcertain dietary components are associated with lowerAZA risk )Amin and Hamza,2005; Karawya and El-Nahas, 2006). These include vitamins as well as otherphytochemicals, polyphenols

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