Abstract

SUMMARY 1 Dried bonito (katsuo-bushi) is a traditional food in Japan. Previous studies have shown that dried-bonito broth (DBB) lowers blood pressure in hypertensive rats; however, the effect on blood pressure in humans has not been investigated. 2 The objective of this study was to clarify the effect of DBB on blood pressure and an oxidative stress marker, urinary 8-hydroxydeoxyguanosine (8-OHdG), in a human clinical trial. 3 A randomized grouping study was carried out using a cross-over design. The elderly subjects ingested DBB or water twice a day for 1 month, with a 1 month washout period. Blood pressure and the 8-OHdG level in urine were measured before and after the ingestion period. 4 In the subjects with higher blood pressure, systolic blood pressure and the level of 8-OHdG decreased significantly during the period in which DBB was ingested, whereas no significant changes were observed for water ingestion. There were no significant changes in subjects with optimum blood pressure. These results suggest that DBB lowered systolic blood pressure and the level of 8-OHdG in elderly subjects with higher blood pressure.

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