Effect of Doxorubicin on Locomotion Stimulation, Depression andCatechol Amines (Dopamine and 5HT)

Abstract

Aim: To determine the effect of doxorubicin on locomotion, stimulation, depression and catechol amines (dopamine and 5HT). Methods: Experimental drug doxorubicin was used as an anticancer drug. It was dissolved in saline and injected intraperitoneally to test group of rats. It was observed very little has been reported on the behavioural effects. Three behavioural studies were observed, which include open field activity specific for locomotion, light and dark activity specific for depression, and home cage activity specific for stimulation after one week, two weeks, three weeks and four weeks of doxorubicin treatments. To determine the concentration of dopamine and 5HT in brain, rats were decapitated gradually and analysed by HPLC-EC detector, results were observed very carefully. Results: Locomotors activity and stimulatory activity were decreased when the concentration of doxorubicin increased gradually and depression was markedly appeared. The mean value of dopamine and 5HT were decreased markedly in TG group of rats as compared to CG group of rats. Conclusion: Doxorubicin has negative effect on locomotion and stimulation, but produces the positive effect on depression. These activities were depending upon the concentrations of catecholamine’s (dopamine and 5HT). It was also observed that dopamine and 5HT were also significantly decreased.