Abstract
Incorporation of amino acids into proteins in a cell-free system derived from rabbit reticulocytes was inhibited by either natural (reovirus) or synthetic (poly I:poly C) double-stranded RNAs. The optimal concentration for this inhibition was approximately 0.1 μg/ml. No inhibition was observed following treatment of a cell-free protein synthesizing system derived from wheat germ embryos with double-stranded RNAs at concentrations up to 10 μg/ml. Wheat germ extracts were examined for the presence of a nucleolytic activity capable of digesting double-stranded RNA. No such activity could be detected. A possible explanation for the difference in effect of double-stranded RNA on the two systems is discussed.
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