Abstract
Hind limbs of mice were irradiated to 2500 rad at dose rates of 4.2, 20.9, 73.7, 190.0 and 367.0 rad/min. Early skin reactions were assessed over a period of 1–50 days post irradiation. Skin reactions after 4.2 and 20.9 rad/min were less severe than those at the higher dose rates. At seven months post irradiation, irradiated tissues of surviving mice were evaluated histologically. The 4.2 and 20.9 rad/min groups showed less late damage to tissues than did the higher dose rate groups. At 5 months post irradiation, mice who survived the initial radiation treatment (4.2, 20.9 and 367.0 rad/min groups only) were reirradiated with a single dose of 1500 rad and skin reactions were assessed. Severe skin damage was seen, with a biphasic pattern of temporal development.
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