Abstract
The effect of dose rate on intestinal tolerance after 60Co γ-irradiation has been studied in BALB/c mice. Intestinal tolerance was assessed from LD50, after either selective abdominal irradiation or total-body irradiation. Three dose rates were compared: 0.6 Gy/min (“acute irradiation” taken as reference), 0.05 Gy/min and 0.025 Gy/min.; the corresponding irradiation times were then about 20 min, 5 h and 12 h respectively. Irradiations were performed simultaneously, at these dose rates, with three telecobalt therapy units; the dose rates were adjusted with lead shields and by increasing the distances. For abdominal irradiations the animals were immobilized with legs stretched by means of wooden clothes-pegs (Wambersie et al., 1974). The immobilization times were the same (about 12 h) for all animals; they could bear it without anaesthesia.
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