Abstract
The objective of this study was to determine the pharmacokinetics of tolfenamic acid (TA) following intravenous (IV) administration at doses of 2 and 4mg/kg in goats. In this study, six healthy goats were used. TA was administered intravenously to each goat at 2 and 4mg/kg doses in a cross-over pharmacokinetic design with a 15-day washout period. Plasma concentrations of TA were analyzed using the high performance liquid chromatography with ultraviolet detector, and pharmacokinetic parameters were assigned by noncompartmental analysis. Following IV administration at dose of 2mg/kg, area under the concentration-time curve (AUC0-∞ ), elimination half-life (t1/2ʎz ), total clearance (ClT ) and volume of distribution at steady state (Vdss ) were 6.64±0.81hr* µg/ml, 1.57±0.14hr, 0.30±0.04 Lh-1 kg-1 and 0.40±0.05L/kg, respectively. After the administration of TA at a dose of 4mg/kg showed prolonged t1/2ʎz , increased dose-normalized AUC0-∞ , and decreased ClT . In goats, TA at 4mg/kg dose can be administered wider dose intervals compared to the 2mg/kg dose. However, further studies are needed to determine the effect of different doses on the clinical efficacy of TA in goats.
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