Abstract
It was demonstrated previously that the median survival time (MST) of rats exposed to low temperature was decreased when cold challenge was immediately preceded by whole-body x-irradiation. To determine if the decreased tolerance of irradiated rats to cold was the result of radiation damage to specific sites, partial-body irradiation studies were conducted. Survival times at -17°C were determined for groups of juvenile male rats that were exposed to cold within 130 minutes after x-irradiation (1000 rad) of the head, body, hindquarters, or the whole body. The MST's of the head, body, and whole-body irradiated groups were similar, and were significantly less than that of the nonirradiated control group. No radiation-induced reduction in survival time in the cold was observed in the hindquarters-irradiated group, even though the irradiated mass was about twice that of the head group. After a radiation dose of 500 rad, cold tolerance was equally reduced by body or whole-body irradiation, but not affected when...
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