Effect of doped functional bioceramic on in vitro degradation and histocompatibility of poly(l-lactide-trimethylene carbonate-glycolide) terpolymers

Abstract

The effects of modified calcium carbonate whisker (CCW) and two modified mesoporous silica (SBA-15, MCM-41) bioceramic on the degradation behavior of pure poly(L-lactide-co-trimethylene carbonate-co-glycolide) (PLTG) terpolymer in PBS buffer solution were investigated. Compared with pure PLTG, the addition of inorganic particles can neutralize the acidic products produced during the degradation process and maintain the pH of the system. At the same time, the addition of inorganic particles improves the hydrophilicity of the composite and accelerates the initial degradation rate of the polymer matrix. However, with the prolongation of the degradation time, different inorganic particles show different degradation rate adjustment effects. Because of the barrier effect of the hexagonal phase structure of SBA-15 and MCM-41 mesoporous materials on the diffusion of water molecules and the compatibility with the PLTG matrix is better than that of solid CCW, the addition of mesoporous materials slows down the degradation of the PLTG matrix. The addition of CCW accelerated the autocatalytic degradation of PLTG. It can be seen that the in vitro degradation rate of composite materials can be regulated by adding different inorganic particles, which has important reference value for the artificial regulation of the degradation rate of composite materials. According to the H&E staining appearance, all samples present good histocompatibility. These results suggest that the terpolymer with 5 wt% mesoporous nanoparticles adding is promising for uses as fully biodegradable bone repair scaffold.