Effect of domperidone to increase breast milk volume

Abstract

Mother's own breast milk is considered to be the optimal form of nutrition for all infants. Its use has been associated with a reduction in neonatal morbidities and improvements in neurodevelopmental outcome. Despite this compelling data, a significant discrepancy remains between the rates of breastfeeding initiation and the rates examining duration and exclusivity of breastfeeding. While the reasons for this decline are multifactorial, actual or perceived concerns regarding milk supply are common. Non-pharmacological measures considered to be the first choice for the treatment of low milk supply have been associated with a variable level of success in augmenting milk production. Thus, the use of a pharmacological agent is often prescribed. Many questions remain regarding the role and best option of galactogogues. Domperidone, a dopamine antagonist, is an effective treatment for most mothers with insufficient milk supply. Even at low doses, domperidone has been associated with increases in milk volumes in some women experiencing insufficient milk production. However, further study related to the optimal dose, duration of treatment, and safety consideration of both mothers and their infants is needed.