Abstract
The thermodynamic parameters of an antiparallel G-quartet formation of d(G 4T 4G 4) with 1 mM divalent cation (Mg 2+, Ca 2+, Mn 2+, Co 2+, and Zn 2+) were obtained. The thermodynamic parameters showed that the divalent cation destabilizes the antiparallel G-quartet of d(G 4T 4G 4) in the following order: Zn 2+>Co 2+>Mn 2+>Mg 2+>Ca 2+. In addition, a higher concentration of a divalent cation induced a transition from an antiparallel to a parallel G-quartet structure. These results indicate that these divalent cations are a good tool for regulating the G-quartet structures.
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