Abstract
The reversible formation of SS-bridges between chromosomal proteins has been suggested to be involved in the chromatin and chromosome contraction process. This study investigated the effect of simultaneous in vitro exposure of human lymphoid cells to dithioerythritol (DTE) and colchicine for 4 or 20 h on metaphase chromosome length. The results show that DTE exposure induced small changes towards longer average chromosome length. The difference was statistically significant when samples drawn from cultures exposed to the highest concentration of DTE (10-3M) were compared to those drawn from cultures exposed only to colchicine. Chromosomal contraction induced by 3 h exposure to colchicine could be partially reversed by hypotonic treatment with solutions of DTE. The results corroborate other studies suggesting involvement of SS-bridge formation in chromosome contraction.
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